NEUROGENETICSSilvia Paracchini Research Group
We are studying the genetic basis of complex cognitive and behavioural phenotypes. In particular we focus on the biology of dyslexia, a specific impairment in learning to read which is caused in large part by genetic factors. We are also interested in cognitive traits related to dyslexia such as general reading and language abilities.
More recently we have become interested in handedness and in a complex link between dyslexia and laterality. We are using large scale screening involving genome-wide and functional genomics approaches to identify candidate genes or loci underlying these phenotypes. In parallel we are developing functional assays to understand the biological mechanisms that mediate genetic differences to phenotypic variation.
First in-person meeting abroad since the pandemic! Silvia gave a seminar at CBM in Madrid, hosted by Dr Claudio Toma, where she had the opportunity to discuss projects and potential collaborations.
Our study invesitgating the link between dyslexia and language impairment is out in preprint https://psyarxiv.com/74jsd . A collaboration led by Filippo and made possible thanks to our GenLang partners.
Check out our new study led by Judith on the heritability and parental effects of laterality measures https://www.nature.com/articles/s41398-022-01834-z/
New study led by Rebeca Diaz and Nils Krononberg reporting the characterisation of the KIAA0319 using a combination of biophotonics and cell biology assays is now out in Scientific Reports. Our work shows a role of this gene in cilia biology and in mediating...
The latest review on dyslexia genetics written with Florina Erbeli and Marianne Rice is now available at https://www.mdpi.com/2076-3425/12/1/27